Hutchinson-Guildford progeria syndrome in Drosophila
In humans, Hutchinson-Guildford progeria syndrome is caused by mutations in the LMNA gene. In Drosophila, there are two lamin genes: lamC and Dm0. Previous studies have shown that Drosophila and vertebrate lamin genes share a common ancestor. Drosophila lamin null mutations lead to lethality (either pupal lethality or complete pre-metamorphosis lethalit, depending on which type of lamin). A recent study by Gemma Beard and colleagues looked at ectopic expression of progerin and human lamin A in Drosophila.
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