perdurance

January 9, 2009 at 8:18 am (drosophila, genetics, mitotic exchange, perdurance) (, , , )

In 1971, Antonio Garcia-Bellido and John Merriam introduced the concept of perdurance to describe the persistence of a gene’s product after the removal of a gene from a cell. For example, if by mitotic exchange a m/m cell is made from a m/m+ progenitor, how long does the product of the wild-type allele m+ persist as the clone of m/m cells expands?

Garcia-Bellido, A. and J.R. Merriam. 1971. Genetic analysis of cell heredity in imaginal discs of Drosophila melanogaster. Proc. Natl. Acad. Sci. 68: 2222-2226.

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