donepezil and memantine can reverse age-induced memory problems in mice

Christophe Tronche and colleagues have recently studied the effects of donepezil and memantine treatment (mainly used for mild to severe forms of Alzheimer’s diseases) on age-induced memory impairments. And they found that these pharmacological compounds can reverse memory problems related to contextual and serial discrimination in mice.

“… develop in mice a task (contextual and serial discrimination, CSD) allowing to study simultaneously in the same animal memory of flexible information (i.e. contextually and temporally distinct information) and of invariant ones (allocentric spatial information) [2][4][5][7][8] and [34]. This task resemble to the “one-trial objec –context recognition task”’ also developed previously in mice by Dere et al. [14][15][16] and [17] involving object recognition in different spatio-temporal contexts. Thus, the first part of this article will describe these two mice models of “episodic-like” memory, in which the specific context of the to be remembered information play a key role in memory performance …

… The development of these animal models is of importance to modelise human memory pathologies or dysfunction. More specifically, numerous clinical studies agree on the fact that one of the main factors responsible for the deleterious effects of aging on episodic memory in humans is the progressive weaknesses of elderly to use the contextual and temporal cues of the to be remembered information [1][18] and [32]. Thus, the second part of this article will focuses on describing the deleterious effects of aging in the CSD task; in a third part, the effects in the CSD task of two main pharmacological compounds used in the treatment of moderate to severe forms of Alzheimer’s disease, namely donepezil (an anticholinesterase compound) andmemantine (an NMDA blocker) will be compared to pharmacological compounds acting on other neurotransmitter targets (nicotinic and AMPA receptors) promising for the treatment of age-related amnesia …”

Behavioural Brain Research
Volume 215, Issue 2, 31 December 2010, Pages 255-260
Pharmacological modulation of contextual “episodic-like” memory in aged mice 

C. TroncheP. LestageC. LouisI. Carrie and D. Béracochéa

doi:10.1016/j.bbr.2010.04.009

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Filed under ageing, ageing brain, Alzheimer's Disease, memory, memory loss

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