Category Archives: biology
Drosophila CG6539 is orthologue of vertebrate gemin3
Mutations in the survival motor neuron (SMN1) gene cause spinal muscular atrophy (SMA), an autosomal recessive disorder characterised by degeneration of spinal cord motor neurons leading to progressive muscular weakness. SMN1 encodes an RNA-binding protein, SMN, which is complexed with … Continue reading
Filed under biochemistry, biological sciences, biology, cell biology, deletion, drosophila, helicase, lethality, life sciences, science
gene cluster hypothesis
Gustavo Barja discussed the gene cluster hypothesis of ageing and longevity on the journal Biogerontology. Barja G. The gene cluster hypothesis of aging and longevity. Biogerontology. 2008 Feb;9(1):57-66. Epub 2007 Oct 31. “… the life extension effect of single gene … Continue reading
human exonuclease 1 and BLM helicase
In a recent paper by Amitabh Nimonkar and colleagues, it was established that human BLM helicase, a member of the RecQ family, stimulates human exonuclease 1 (hExo1), a 5′ – 3′ double-stranded DNA exonuclease … “Stimulation of DNA resection by … Continue reading
Sarah Palin and the fruitfly
I know this is passe, but just for the record … on her criticism about unyielding pet projects, one example that popped into her head — fruitfly research … “I kid you not” … have a look on youtube … … Continue reading
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
mitochondrial DNA subunits
Rajindar Sohal and colleagues recently made a study comparing the expression of mitochondrial DNA encoded subunits of cytochrome c oxidase (CcO) in Drosophila melanogaster. They compared mitochondrial proteins from 15-, 25-, 35-, 47- and 60-day-old flies. Subunits I, II and … Continue reading
Filed under ageing, aging, biology, drosophila, genetics, mitochondrial DNA, molecular biology
