Category Archives: DNA repair
DNA cleavage by type II and IA topoisomerases
Brian Schmidt and colleagues presented a “novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases” on Nature 465: 641–644 (03 June 2010). Below is part of the abstract: “Here we present the structure of the … Continue reading
structural and biophysical studies of PARP-1
There was an article on the Journal of Molecular Biology (Issue 5, Volume 395, 5 February 2010, pages 983-994) which presented structural and biophysical information about the human PARP-1 protein. PARP-1, or poly(ADP-ribose) polymerase-1 is an enzyme that monitors DNA … Continue reading
Filed under biophysics, DNA, DNA damage, DNA repair, DNA-binding protein
exponential relationship between DNA-end binding activity and maximum longevity
In a recent study published in the journal Mechanisms of Ageing and Development, Antonello Lorenzini and colleagues observed a novel relationship between the capacity of nuclear proteins to bind DNA ends and the longevity of mammalian species. This activity increases … Continue reading
BLAP75/Rmi1
Liudmila Chelysheva and colleagues studied BLAP75/Rmi1 in relation to BLM/Sgs1 and TopoIIIα/Top3. Their paper appeared on the December 2008 issue of PLoS Genetics journal. Below is the summary: “Recombination is a process by which cells can repair DNA damage. Such … Continue reading
Filed under DNA damage, DNA repair, genetics, genome stability
ATR and H2AX
Last month (December 2008) in the Journal of Biological Chemistry, Rebecca Chanoux and colleagues reported the results of their studies on ATR and H2AX. They wrote: “If ATR prevents the collapse of stalled replication forks into DSBs, and H2AX facilitates … Continue reading
WRN and MUS81
There is a Journal of Cell Biology paper by Annapaola Franchitto and colleagues entitled: Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway Below is tha abstract: Failure to stabilize and properly process stalled … Continue reading
WRN protects against cytotoxicity of topotecan but not etoposide
Markus Christmann and colleagues recently reported their findings on whether DNA helicases, like WRN, are involved in the repair of topoisomerase inhibitor-induced DNA damage. “[24] M. Poot, K.A. Gollahon and P.S. Rabinovitch, Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced … Continue reading
Filed under ageing, DNA repair, WRN
human exonuclease 1 and BLM helicase
In a recent paper by Amitabh Nimonkar and colleagues, it was established that human BLM helicase, a member of the RecQ family, stimulates human exonuclease 1 (hExo1), a 5′ – 3′ double-stranded DNA exonuclease … “Stimulation of DNA resection by … Continue reading
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
