Category Archives: fruitfly
sestrins and ageing
The kinase molecule TOR (target of rapamycin) is involved in cell growth and proliferation by increasing protein and lipid synthesis. Persistent activation of TOR causes an imbalance in cellular metabolic processes, leading to the accumulation of reactive oxygen species (ROS). … Continue reading
Filed under 4EBP, ageing, aging, drosophila, fly, fruitfly, mitochondria, reactive oxygen species, ROS, sestrins, structural biology, target of rapamycin, TOR
amino acid imbalance explains lifespan extension by dietary restriction in fruitflies
A study by Richard Grandison, Matthew Piper, and Linda Partridge (Nature advance online publication 2 December 2009 | doi:10.1038/nature08619) has identified the nutrients producing the responses of lifespan and fecundity to dietary restriction (DR) in the fruitfly Drosophila. “Adding essential … Continue reading
Filed under amino acids, dietary restriction, DR, drosophila, fecundity, fertility, fly, fruitfly, lifespan, lifespan extension
flies fed an “anti-Atkins” low protein diet live longer
Researchers at the Buck Institute are studying the regulation of mitochondrial genes in the fruitfly Drosophila melanogaster in relation to ageing and lifespan. They are trying to understand how mitochondrial function relates to diet and energy metabolism, specifically the molecular … Continue reading
Filed under 4EBP, ageing, aging, anti-ageing, anti-aging, Atkins diet, diet, dietary restriction, DR, drosophila, fly, fruitfly, lifespan, longevity, low-protein diet, mitochondrial DNA, rapamycin, target of rapamycin, TOR
ends-out gene targeting
Juan Huang and colleagues describe several approaches to improve crosses in ends-out gene targeting. They generated new sets of targeting vectors and fly stocks and introduced a novel negative selection marker, reducing the frequency of false-positive targeting candidates. Figure 1. … Continue reading
Filed under drosophila, fly, fruitfly, genetics
