Category Archives: genome stability
BLAP75/Rmi1
Liudmila Chelysheva and colleagues studied BLAP75/Rmi1 in relation to BLM/Sgs1 and TopoIIIα/Top3. Their paper appeared on the December 2008 issue of PLoS Genetics journal. Below is the summary: “Recombination is a process by which cells can repair DNA damage. Such … Continue reading
Filed under DNA damage, DNA repair, genetics, genome stability
ATR and H2AX
Last month (December 2008) in the Journal of Biological Chemistry, Rebecca Chanoux and colleagues reported the results of their studies on ATR and H2AX. They wrote: “If ATR prevents the collapse of stalled replication forks into DSBs, and H2AX facilitates … Continue reading
telomere loss produces genomic instability
Simon Titen and Kent Golic studied telomere loss by breakage of an induced dicentric chromosome in the fruitfly Drosophila melanogaster [Genetics 2008 Dec;180(4):1821-32; Epub 2008 Oct 9]. They found that one outcome of this is cell death through Chk2 and … Continue reading
Holliday junction resolvases
The formation of four-way DNA junctions, Holliday junctions, account for products formed during meiotic recombination. These junctions are involved recombinational repair of DNA double-stranded breaks. Resolvases are small homodimeric enzymes that resolve Holliday junctions by endonucleolytic cleavage. Resolution is achieved … Continue reading
Filed under ageing, genome stability
