Category Archives: lifespan
life expectancy in the UK
A recent update from the UK Statistics Authority indicated that life expectancy in England has continued to increase for both males and females, reaching 78.0 and 82.1 years respectively in 2007-09. In addition, premature mortality rates from circulatory diseases for … Continue reading
Filed under ageing, life expectancy, lifespan
review on lifespan extension
There is a new review on Science (by Luigi Fontana, Linda Partridge, and Valter Longo) discussing recent findings in ageing research supporting the idea that lifespan can be extended by dietary and genetic alterations. Many studies have shown that reducing … Continue reading
Filed under lifespan, lifespan extension, reviews
exponential relationship between DNA-end binding activity and maximum longevity
In a recent study published in the journal Mechanisms of Ageing and Development, Antonello Lorenzini and colleagues observed a novel relationship between the capacity of nuclear proteins to bind DNA ends and the longevity of mammalian species. This activity increases … Continue reading
amino acid imbalance explains lifespan extension by dietary restriction in fruitflies
A study by Richard Grandison, Matthew Piper, and Linda Partridge (Nature advance online publication 2 December 2009 | doi:10.1038/nature08619) has identified the nutrients producing the responses of lifespan and fecundity to dietary restriction (DR) in the fruitfly Drosophila. “Adding essential … Continue reading
Filed under amino acids, dietary restriction, DR, drosophila, fecundity, fertility, fly, fruitfly, lifespan, lifespan extension
flies fed an “anti-Atkins” low protein diet live longer
Researchers at the Buck Institute are studying the regulation of mitochondrial genes in the fruitfly Drosophila melanogaster in relation to ageing and lifespan. They are trying to understand how mitochondrial function relates to diet and energy metabolism, specifically the molecular … Continue reading
Filed under 4EBP, ageing, aging, anti-ageing, anti-aging, Atkins diet, diet, dietary restriction, DR, drosophila, fly, fruitfly, lifespan, longevity, low-protein diet, mitochondrial DNA, rapamycin, target of rapamycin, TOR
synaptic proteins, IGF signaling, and lifespan
In a paper by QueeLim Ch’ng and colleagues, a genetic analysis of presynaptic structure in the worm Caenorhabditis elegans was described after measuring in vivo changes in the distribution of fluorescently tagged presynaptic proteins. Because changes in the abundance of … Continue reading
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
