Category Archives: longevity
TOR signaling never gets old
Daniel Evans and colleagues wrote a review recently about TOR: “The target of rapamycin (TOR) signal transduction network monitors intra- and extracellular conditions that favor cell growth. Research during the last decade has revealed a modular structure of the TOR … Continue reading
Filed under ageing, aging, longevity, target of rapamycin, TOR
exponential relationship between DNA-end binding activity and maximum longevity
In a recent study published in the journal Mechanisms of Ageing and Development, Antonello Lorenzini and colleagues observed a novel relationship between the capacity of nuclear proteins to bind DNA ends and the longevity of mammalian species. This activity increases … Continue reading
flies fed an “anti-Atkins” low protein diet live longer
Researchers at the Buck Institute are studying the regulation of mitochondrial genes in the fruitfly Drosophila melanogaster in relation to ageing and lifespan. They are trying to understand how mitochondrial function relates to diet and energy metabolism, specifically the molecular … Continue reading
Filed under 4EBP, ageing, aging, anti-ageing, anti-aging, Atkins diet, diet, dietary restriction, DR, drosophila, fly, fruitfly, lifespan, longevity, low-protein diet, mitochondrial DNA, rapamycin, target of rapamycin, TOR
rapamycin increases lifespan in mice
Lynne Cox wrote an article on the BSRA News Section about the recent Nature paper by David Harrison and colleagues: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice; Nature 460, 392-395 (16 July 2009); doi:10.1038/nature08221; Published online … Continue reading
Filed under ageing, aging, anti-ageing, anti-aging, longevity, mice, rapamycin
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
