Category Archives: molecular biology

December 22, 2008

telomere loss produces genomic instability

Simon Titen and Kent Golic studied telomere loss by breakage of an induced dicentric chromosome in the fruitfly Drosophila melanogaster [Genetics 2008 Dec;180(4):1821-32; Epub 2008 Oct 9]. They found that one outcome of this is cell death through Chk2 and … Continue reading →

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Filed under biochemistry, cell biology, chromosomal defect, DNA damage, drosophila, FLP recombinase, genetics, genome, genome stability, molecular biology, recombination

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October 31, 2008

human exonuclease 1 and BLM helicase

In a recent paper by Amitabh Nimonkar and colleagues, it was established that human BLM helicase, a member of the RecQ family, stimulates human exonuclease 1 (hExo1), a 5′ – 3′ double-stranded DNA exonuclease … “Stimulation of DNA resection by … Continue reading →

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Filed under biochemistry, biology, DNA, DNA repair, double strand break, exonuclease, genetics, helicase, homologous recombination, molecular biology

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October 29, 2008

WRN mini-review

In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading →

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Filed under ageing, aging, biological sciences, biology, DNA, DNA repair, double strand break, exonuclease, genetics, helicase, homologous recombination, lifespan, longevity, molecular biology, nucleus, science, Werner Syndrome, Werners Syndrome, WRN

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October 10, 2008

rDNA and recombination

In a mini-review by Ellen Tsang and Anthony Carr, recombination is highly regulated in the rDNA. Repetitive sequences such as rDNA provide good substrates for homologous recombination, particualrly if replication forks collapse here. Several studies have shown that replication fork … Continue reading →

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Filed under ageing, aging, biology, DNA, DNA repair, double strand break, gene, genetics, homologous recombination, molecular biology, recombination, replication, s. cerevisiae, saccharomyces cerevisiae, science, sirtuin, yeast

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October 8, 2008

mitochondrial DNA subunits

Rajindar Sohal and colleagues recently made a study comparing the expression of mitochondrial DNA encoded subunits of cytochrome c oxidase (CcO) in Drosophila melanogaster. They compared mitochondrial proteins from 15-, 25-, 35-, 47- and 60-day-old flies. Subunits I, II and … Continue reading →

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Filed under ageing, aging, biology, drosophila, genetics, mitochondrial DNA, molecular biology

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