Category Archives: recombination

January 7, 2009

ATR and H2AX

Last month (December 2008)  in the Journal of Biological Chemistry, Rebecca Chanoux and colleagues reported the results of their studies on ATR and H2AX. They wrote: “If ATR prevents the collapse of stalled replication forks into DSBs, and H2AX facilitates … Continue reading →

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Filed under ATR, biochemistry, DNA, DNA damage, DNA repair, double strand break, genetics, genome stability, H2A.X, homologous recombination, recombination

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December 22, 2008

telomere loss produces genomic instability

Simon Titen and Kent Golic studied telomere loss by breakage of an induced dicentric chromosome in the fruitfly Drosophila melanogaster [Genetics 2008 Dec;180(4):1821-32; Epub 2008 Oct 9]. They found that one outcome of this is cell death through Chk2 and … Continue reading →

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Filed under biochemistry, cell biology, chromosomal defect, DNA damage, drosophila, FLP recombinase, genetics, genome, genome stability, molecular biology, recombination

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December 9, 2008

WRN and MUS81

There is a Journal of Cell Biology paper by Annapaola Franchitto and colleagues entitled: Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway Below is tha abstract: Failure to stabilize and properly process stalled … Continue reading →

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Filed under ageing, biogerontology, cell biology, DNA, DNA damage, DNA repair, double strand break, endonuclease, genetics, recombination, replication, Werner Syndrome, Werners Syndrome

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October 10, 2008

rDNA and recombination

In a mini-review by Ellen Tsang and Anthony Carr, recombination is highly regulated in the rDNA. Repetitive sequences such as rDNA provide good substrates for homologous recombination, particualrly if replication forks collapse here. Several studies have shown that replication fork … Continue reading →

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Filed under ageing, aging, biology, DNA, DNA repair, double strand break, gene, genetics, homologous recombination, molecular biology, recombination, replication, s. cerevisiae, saccharomyces cerevisiae, science, sirtuin, yeast

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