Category Archives: science

changes in The EMBO Journal

The EMBO Journal implements new intiatives for 2009. It will follow a transparent editorial process for a more constructive referee and author argumentation. In addition,  citing primary literature is being encouraged whenever possible. References are now excluded from the character … Continue reading

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DSB DNA repair genotype predictive of later mortality

A number of pathways operate to repair DNA damage: nucleotide excision repair (NER), base excision repair (BER), double-strand breaks (DSB), and mismatch repair (MMR). In a study by David Neasham and colleagues, single nucleotide polymorphisms in 16 DNA repair genes … Continue reading

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Filed under cancer, DNA, DNA damage, DNA repair, double strand break, dying, gene, genetics, life sciences, mortality, research, science

the scientist and the identifier

“Initiatives such as OpenID (http://openid.net/) and ResearcherID (http://www.researcherid.com/), if they catch on in the scientific community, promise to provide us with unique identifiers.” Philip Bourne and J. Lynn Fink wrote on the journal PLoS Computational Biology. Bourne PE, Fink JL … Continue reading

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Drosophila CG6539 is orthologue of vertebrate gemin3

Mutations in the survival motor neuron (SMN1) gene cause spinal muscular atrophy (SMA), an autosomal recessive disorder characterised by degeneration of spinal cord motor neurons leading to progressive muscular weakness. SMN1 encodes an RNA-binding protein, SMN, which is complexed with … Continue reading

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Filed under biochemistry, biological sciences, biology, cell biology, deletion, drosophila, helicase, lethality, life sciences, science

WRN mini-review

In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading

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Filed under ageing, aging, biological sciences, biology, DNA, DNA repair, double strand break, exonuclease, genetics, helicase, homologous recombination, lifespan, longevity, molecular biology, nucleus, science, Werner Syndrome, Werners Syndrome, WRN

rDNA and recombination

In a mini-review by Ellen Tsang and Anthony Carr, recombination is highly regulated in the rDNA. Repetitive sequences such as rDNA provide good substrates for homologous recombination, particualrly if replication forks collapse here. Several studies have shown that replication fork … Continue reading

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Filed under ageing, aging, biology, DNA, DNA repair, double strand break, gene, genetics, homologous recombination, molecular biology, recombination, replication, s. cerevisiae, saccharomyces cerevisiae, science, sirtuin, yeast