Category Archives: target of rapamycin
structural conservation in TOR pathway
In the Journal of Molecular Biology, there is now a crystal structure of yeast Gse1p, or Gse1p/Ego3p/Slm4p/Nir1p, a component of the EGO-GSE protein complex in endosomal and vacuolar membranes of Saccharomyces cerevisiae. Deletion of genes encoding the proteins that make … Continue reading
TOR signaling never gets old
Daniel Evans and colleagues wrote a review recently about TOR: “The target of rapamycin (TOR) signal transduction network monitors intra- and extracellular conditions that favor cell growth. Research during the last decade has revealed a modular structure of the TOR … Continue reading
Filed under ageing, aging, longevity, target of rapamycin, TOR
sestrins and ageing
The kinase molecule TOR (target of rapamycin) is involved in cell growth and proliferation by increasing protein and lipid synthesis. Persistent activation of TOR causes an imbalance in cellular metabolic processes, leading to the accumulation of reactive oxygen species (ROS). … Continue reading
Filed under 4EBP, ageing, aging, drosophila, fly, fruitfly, mitochondria, reactive oxygen species, ROS, sestrins, structural biology, target of rapamycin, TOR
flies fed an “anti-Atkins” low protein diet live longer
Researchers at the Buck Institute are studying the regulation of mitochondrial genes in the fruitfly Drosophila melanogaster in relation to ageing and lifespan. They are trying to understand how mitochondrial function relates to diet and energy metabolism, specifically the molecular … Continue reading
Filed under 4EBP, ageing, aging, anti-ageing, anti-aging, Atkins diet, diet, dietary restriction, DR, drosophila, fly, fruitfly, lifespan, longevity, low-protein diet, mitochondrial DNA, rapamycin, target of rapamycin, TOR
