Category Archives: Werner Syndrome
WRN RQC
Ken Kitano and colleagues have co-crystallised the RecQ C-terminal (RQC) domain of human WRN bound to a DNA duplex. In their recent Structure paper, they describe how the RQC domain interacts with a blunt end of the duplex and, surprisingly, … Continue reading
Filed under ageing, aging, RecQ, structural biology, Werner Syndrome, WRN
introduction of a normal human chromosome 8 corrects Werner Syndrome cells
Kentaro Ariyoshi and colleagues successfully introduced a normal human chromosome 8 into Werner Syndrome (WS) cells(fibroblasts) immortalized by expressing a human telomere reverse transcriptase subunit (hTERT) gene. In their study (published in the Journal of Radiation Research), they demonstrated that … Continue reading
Filed under progeria, progeroid syndrome, Werner Syndrome, Werners Syndrome, WRN, WS
WRN and MUS81
There is a Journal of Cell Biology paper by Annapaola Franchitto and colleagues entitled: Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway Below is tha abstract: Failure to stabilize and properly process stalled … Continue reading
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
