Category Archives: WRN
WRN RQC
Ken Kitano and colleagues have co-crystallised the RecQ C-terminal (RQC) domain of human WRN bound to a DNA duplex. In their recent Structure paper, they describe how the RQC domain interacts with a blunt end of the duplex and, surprisingly, … Continue reading
Filed under ageing, aging, RecQ, structural biology, Werner Syndrome, WRN
introduction of a normal human chromosome 8 corrects Werner Syndrome cells
Kentaro Ariyoshi and colleagues successfully introduced a normal human chromosome 8 into Werner Syndrome (WS) cells(fibroblasts) immortalized by expressing a human telomere reverse transcriptase subunit (hTERT) gene. In their study (published in the Journal of Radiation Research), they demonstrated that … Continue reading
Filed under progeria, progeroid syndrome, Werner Syndrome, Werners Syndrome, WRN, WS
WRN protects against cytotoxicity of topotecan but not etoposide
Markus Christmann and colleagues recently reported their findings on whether DNA helicases, like WRN, are involved in the repair of topoisomerase inhibitor-induced DNA damage. “[24] M. Poot, K.A. Gollahon and P.S. Rabinovitch, Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced … Continue reading
Filed under ageing, DNA repair, WRN
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
