Tag Archives: DNA repair
DNA cleavage by type II and IA topoisomerases
Brian Schmidt and colleagues presented a “novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases” on Nature 465: 641–644 (03 June 2010). Below is part of the abstract: “Here we present the structure of the … Continue reading
structural and biophysical studies of PARP-1
There was an article on the Journal of Molecular Biology (Issue 5, Volume 395, 5 February 2010, pages 983-994) which presented structural and biophysical information about the human PARP-1 protein. PARP-1, or poly(ADP-ribose) polymerase-1 is an enzyme that monitors DNA … Continue reading
Filed under biophysics, DNA, DNA damage, DNA repair, DNA-binding protein
exponential relationship between DNA-end binding activity and maximum longevity
In a recent study published in the journal Mechanisms of Ageing and Development, Antonello Lorenzini and colleagues observed a novel relationship between the capacity of nuclear proteins to bind DNA ends and the longevity of mammalian species. This activity increases … Continue reading
RecQ and recombination-based DNA repair
Dharmendra Kumar Singh and colleagues wrote an article in the Biogerontology journal presenting the various roles of human RecQ helicases in recombination-based DNA repair. The physiological consequences of RecQ defects in the development of cancer and premature aging were also … Continue reading
Filed under ageing, aging, biogerontology, RecQ
Holliday junction resolvases
The formation of four-way DNA junctions, Holliday junctions, account for products formed during meiotic recombination. These junctions are involved recombinational repair of DNA double-stranded breaks. Resolvases are small homodimeric enzymes that resolve Holliday junctions by endonucleolytic cleavage. Resolution is achieved … Continue reading
Filed under ageing, genome stability
