Tag Archives: double strand break
ATR and H2AX
Last month (December 2008) in the Journal of Biological Chemistry, Rebecca Chanoux and colleagues reported the results of their studies on ATR and H2AX. They wrote: “If ATR prevents the collapse of stalled replication forks into DSBs, and H2AX facilitates … Continue reading
Williams–Beuren syndrome transcription factor and the gamma-H2A.X
Andrew Xiao and colleagues reported their findings (Nature 457, 57-62 ) recently (1 January 2009) about factors that are directly involved in regulating H2A.X. In mammals, H2A.X Ser 139 phosphorylation (-H2A.X) occurs to reorganize chromatin in case of DNA double-strand breakage. … Continue reading
Filed under ageing
WRN and MUS81
There is a Journal of Cell Biology paper by Annapaola Franchitto and colleagues entitled: Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway Below is tha abstract: Failure to stabilize and properly process stalled … Continue reading
