Tag Archives: drosophila
sestrins and ageing
The kinase molecule TOR (target of rapamycin) is involved in cell growth and proliferation by increasing protein and lipid synthesis. Persistent activation of TOR causes an imbalance in cellular metabolic processes, leading to the accumulation of reactive oxygen species (ROS). … Continue reading
Filed under 4EBP, ageing, aging, drosophila, fly, fruitfly, mitochondria, reactive oxygen species, ROS, sestrins, structural biology, target of rapamycin, TOR
Linda
Today, Dame Linda Partidge will give a talk. I’m quite excited to see and listen. If you do not know her, visit the Royal Society, and watch her Croonian Prize Lecture on the new biology of ageing. “She holds the … Continue reading
Filed under ageing, amino acids, anti-ageing, linda
flies fed an “anti-Atkins” low protein diet live longer
Researchers at the Buck Institute are studying the regulation of mitochondrial genes in the fruitfly Drosophila melanogaster in relation to ageing and lifespan. They are trying to understand how mitochondrial function relates to diet and energy metabolism, specifically the molecular … Continue reading
Filed under 4EBP, ageing, aging, anti-ageing, anti-aging, Atkins diet, diet, dietary restriction, DR, drosophila, fly, fruitfly, lifespan, longevity, low-protein diet, mitochondrial DNA, rapamycin, target of rapamycin, TOR
maternally inherited piRNAs
In hybrid dysgenesis (Drosophila melanogaster), the progeny of intercrosses between wild males and laboratory-strain females are sterile because of defects in gamete formation. This has something to do with the mobilization of transposons. Depending on the parent of transposon origin, … Continue reading
Filed under females
Drosophila CG6539 is orthologue of vertebrate gemin3
Mutations in the survival motor neuron (SMN1) gene cause spinal muscular atrophy (SMA), an autosomal recessive disorder characterised by degeneration of spinal cord motor neurons leading to progressive muscular weakness. SMN1 encodes an RNA-binding protein, SMN, which is complexed with … Continue reading
Filed under biochemistry, biological sciences, biology, cell biology, deletion, drosophila, helicase, lethality, life sciences, science
mitochondrial DNA subunits
Rajindar Sohal and colleagues recently made a study comparing the expression of mitochondrial DNA encoded subunits of cytochrome c oxidase (CcO) in Drosophila melanogaster. They compared mitochondrial proteins from 15-, 25-, 35-, 47- and 60-day-old flies. Subunits I, II and … Continue reading
Filed under ageing, aging, biology, drosophila, genetics, mitochondrial DNA, molecular biology
