Tag Archives: DSB

January 8, 2009

DSB DNA repair genotype predictive of later mortality

A number of pathways operate to repair DNA damage: nucleotide excision repair (NER), base excision repair (BER), double-strand breaks (DSB), and mismatch repair (MMR). In a study by David Neasham and colleagues, single nucleotide polymorphisms in 16 DNA repair genes … Continue reading →

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Filed under cancer, DNA, DNA damage, DNA repair, double strand break, dying, gene, genetics, life sciences, mortality, research, science

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January 7, 2009

ATR and H2AX

Last month (December 2008)  in the Journal of Biological Chemistry, Rebecca Chanoux and colleagues reported the results of their studies on ATR and H2AX. They wrote: “If ATR prevents the collapse of stalled replication forks into DSBs, and H2AX facilitates … Continue reading →

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Filed under ATR, biochemistry, DNA, DNA damage, DNA repair, double strand break, genetics, genome stability, H2A.X, homologous recombination, recombination

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December 9, 2008

WRN and MUS81

There is a Journal of Cell Biology paper by Annapaola Franchitto and colleagues entitled: Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway Below is tha abstract: Failure to stabilize and properly process stalled … Continue reading →

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Filed under ageing, biogerontology, cell biology, DNA, DNA damage, DNA repair, double strand break, endonuclease, genetics, recombination, replication, Werner Syndrome, Werners Syndrome

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October 28, 2008

Back from Heidelberg

I’m back from Heidelberg. My original plan was to blog during the entire symposium, but that did not materialize. I will write more about the three days soon. In the meantime, here is an interesting paper on Sgs1 and BLM … Continue reading →

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Filed under ageing, aging

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