Tag Archives: helicase
Drosophila CG6539 is orthologue of vertebrate gemin3
Mutations in the survival motor neuron (SMN1) gene cause spinal muscular atrophy (SMA), an autosomal recessive disorder characterised by degeneration of spinal cord motor neurons leading to progressive muscular weakness. SMN1 encodes an RNA-binding protein, SMN, which is complexed with … Continue reading
Filed under biochemistry, biological sciences, biology, cell biology, deletion, drosophila, helicase, lethality, life sciences, science
BLM helicase as a mousetrap
Robert Brosh, Jr. wrote an article on Nature about the BLM helicase [Nature 456, 453-454 (27 November 2008) | doi:10.1038/456453a; Published online 26 November 2008]. His introductory paragraph goes: “Bloom’s syndrome, which is characterized by severe growth retardation, immunodeficiency, anaemia, … Continue reading
Filed under Bloom's syndrome
human exonuclease 1 and BLM helicase
In a recent paper by Amitabh Nimonkar and colleagues, it was established that human BLM helicase, a member of the RecQ family, stimulates human exonuclease 1 (hExo1), a 5′ – 3′ double-stranded DNA exonuclease … “Stimulation of DNA resection by … Continue reading
Back from Heidelberg
I’m back from Heidelberg. My original plan was to blog during the entire symposium, but that did not materialize. I will write more about the three days soon. In the meantime, here is an interesting paper on Sgs1 and BLM … Continue reading
