Tag Archives: rDNA
rDNA theory of aging
The ribosomes are the most abundant protein complexes in the cell. They are synthesised from ribosomal DNA (rDNA) genes within nucleoli. In most eukaryotic cells, rDNA exists in tandem arrays, which are repeating units of similar sequences. Oftentimes the rDNA … Continue reading
Filed under ageing
rDNA variation
Lawrence Weider and colleagues wrote a review in 2005 covering ribosomal DNA variation. They discussed the interaction between rDNA and growth rate. They also highlighted the role of selection on rDNA variants in the microevolutionary process. They concluded that using … Continue reading
Filed under genetics
perinuclear tethering promotes rDNA repeat stability
Karim Mekhail and colleagues studied a network in the the budding yeast Saccharomyces cerevisiae that stabilizes ribosomal DNA repeats thru interactions between rDNA-associated silencing proteins and proteins of the inner nuclear membrane (INM). They reported that deletion of either the … Continue reading
Filed under ageing
rDNA and epigenetic regulation
Antero Salminen and Kai Kaarnirant wrote a mini review on rDNA and sirtuins — Biochemical and Biophysical Research Communications journal (received 3 November 2008, available online 14 November 2008). They stated that transcription and silencing of rRNA genes are controlled … Continue reading
Filed under ageing, aging, epigenetics, mammals, s. cerevisiae, saccharomyces cerevisiae, yeast
