Tag Archives: recombination
rDNA theory of aging
The ribosomes are the most abundant protein complexes in the cell. They are synthesised from ribosomal DNA (rDNA) genes within nucleoli. In most eukaryotic cells, rDNA exists in tandem arrays, which are repeating units of similar sequences. Oftentimes the rDNA … Continue reading
Filed under ageing
BLAP75/Rmi1
Liudmila Chelysheva and colleagues studied BLAP75/Rmi1 in relation to BLM/Sgs1 and TopoIIIα/Top3. Their paper appeared on the December 2008 issue of PLoS Genetics journal. Below is the summary: “Recombination is a process by which cells can repair DNA damage. Such … Continue reading
Filed under DNA damage, DNA repair, genetics, genome stability
RecQ and recombination-based DNA repair
Dharmendra Kumar Singh and colleagues wrote an article in the Biogerontology journal presenting the various roles of human RecQ helicases in recombination-based DNA repair. The physiological consequences of RecQ defects in the development of cancer and premature aging were also … Continue reading
Filed under ageing, aging, biogerontology, RecQ
ATR and H2AX
Last month (December 2008) in the Journal of Biological Chemistry, Rebecca Chanoux and colleagues reported the results of their studies on ATR and H2AX. They wrote: “If ATR prevents the collapse of stalled replication forks into DSBs, and H2AX facilitates … Continue reading
perinuclear tethering promotes rDNA repeat stability
Karim Mekhail and colleagues studied a network in the the budding yeast Saccharomyces cerevisiae that stabilizes ribosomal DNA repeats thru interactions between rDNA-associated silencing proteins and proteins of the inner nuclear membrane (INM). They reported that deletion of either the … Continue reading
Filed under ageing
human exonuclease 1 and BLM helicase
In a recent paper by Amitabh Nimonkar and colleagues, it was established that human BLM helicase, a member of the RecQ family, stimulates human exonuclease 1 (hExo1), a 5′ – 3′ double-stranded DNA exonuclease … “Stimulation of DNA resection by … Continue reading
