Tag Archives: ribosomal DNA

June 29, 2009

rDNA theory of aging

The ribosomes are the most abundant protein complexes in the cell. They are synthesised from ribosomal DNA (rDNA) genes within nucleoli. In most eukaryotic cells, rDNA exists in tandem arrays, which are repeating units of similar sequences. Oftentimes the rDNA … Continue reading →

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January 12, 2009

rDNA variation

Lawrence Weider and colleagues wrote a review in 2005 covering ribosomal DNA variation. They discussed the interaction between rDNA and growth rate. They also highlighted the role of selection on rDNA variants in the microevolutionary process. They concluded that using … Continue reading →

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December 17, 2008

perinuclear tethering promotes rDNA repeat stability

Karim Mekhail and colleagues studied a network in the the budding yeast Saccharomyces cerevisiae that stabilizes ribosomal DNA repeats thru interactions between rDNA-associated silencing proteins and proteins of the inner nuclear membrane (INM). They reported that deletion of either the … Continue reading →

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October 10, 2008

rDNA and recombination

In a mini-review by Ellen Tsang and Anthony Carr, recombination is highly regulated in the rDNA. Repetitive sequences such as rDNA provide good substrates for homologous recombination, particualrly if replication forks collapse here. Several studies have shown that replication fork … Continue reading →

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Filed under ageing, aging, biology, DNA, DNA repair, double strand break, gene, genetics, homologous recombination, molecular biology, recombination, replication, s. cerevisiae, saccharomyces cerevisiae, science, sirtuin, yeast

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