Tag Archives: WRN
WRN RQC
Ken Kitano and colleagues have co-crystallised the RecQ C-terminal (RQC) domain of human WRN bound to a DNA duplex. In their recent Structure paper, they describe how the RQC domain interacts with a blunt end of the duplex and, surprisingly, … Continue reading
Filed under ageing, aging, RecQ, structural biology, Werner Syndrome, WRN
RecQ and recombination-based DNA repair
Dharmendra Kumar Singh and colleagues wrote an article in the Biogerontology journal presenting the various roles of human RecQ helicases in recombination-based DNA repair. The physiological consequences of RecQ defects in the development of cancer and premature aging were also … Continue reading
Filed under ageing, aging, biogerontology, RecQ
WRN and MUS81
There is a Journal of Cell Biology paper by Annapaola Franchitto and colleagues entitled: Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway Below is tha abstract: Failure to stabilize and properly process stalled … Continue reading
WRN protects against cytotoxicity of topotecan but not etoposide
Markus Christmann and colleagues recently reported their findings on whether DNA helicases, like WRN, are involved in the repair of topoisomerase inhibitor-induced DNA damage. “[24] M. Poot, K.A. Gollahon and P.S. Rabinovitch, Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced … Continue reading
Filed under ageing, DNA repair, WRN
WRN mini-review
In a recent issue of DNA Repair [7 (2008) 1776–1786], Julia Sidorova reviews the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. She … Continue reading
